Role Of Viruses In Odontogenic Tumors – A Systematic Review

Odontogenic lesions can be divided discretely into cysts (an epithelial lined pathological cavity) and tumors (a solid tissue mass, not necessarily neoplastic). They are derived from tooth forming tissues, either the epithelial or the ectomesenchymal or both. They form a heterogeneous group of hamartomatous lesions, benign and malign tumors. According to their origins, they are divided into epithelial, ectomesenchymal, and mesenchymal. Among the most frequent OTs are Keratocystic Odontogenic Tumors (KCOTs), ameloblastomas, and odontomas. Odontogenic tumors are quite rare and constituteless than 1% of all jaw tumors. The KCOT arises from the dental lamina and other sources of odontogenic epithelium. This lesion tends to be more aggressive in its growth pattern, providing a higher recurrence rate than other odontogenic pathoses. Ameloblastomas can be derived from any odontogenic epithelium ranging from the dental lamina (pre-odontogenesis), to reduced enamel epithelium (post-odontogenesis), to epithelial rests of Malassez and Serres (post-eruption), and possibly the basal layer of the overlying epithelium (The primitive source of dental lamina during embryogenesis and pre-odontogenesis). Odontogenic myxomais an intraosseous neoplasm consisting of myxomatous fibrous extracellular matrix originating from mesenchymal remnants. Adenomatoid odontogenic tumors arise from the dental lamina in the gubernacular cord of developing permanent teeth. Ameloblastic fibromas are similar Abstract: Introduction: Odontogenic tumours are neoplasm of the cells or tissues that initiate odontogenic processes. Odontogenic tumours constitute less than 1% of all jaw tumours. Odontogenic tumors are derived from tooth forming tissues, either the epithelial or the ectomesenchymal or both. Viruses such as Epstein Barr virus (EBV), Polyoma virus, Human papilloma virus (HPV), HTLV1 may have a role in pathogenesis and aggressiveness of odontogenic tumours. Aims & Objectives: To review the possible relation of viruses with the odontogenic tumours and to update the evidence on the role of viruses in the etiopathogenesis of odontogenic tumours. Materials & methods: Search strategy– For this systematic review the data were obtained from electronic search engines like PUBMED, GOOGLE J-GATE from 1966 -2017. Results: This systematic review found that onco viruses especially HPV and EBV viruses play a major role in causation of odontogenic tumors by enhancing the pathology by altering the genetic and molecular mechanism. Conclusion: Oncoviruses play a major role in enhancing the pathology of odontogenic tumors.